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To a mixture of 7-iodo 4-dedimethylamino sancycline mono trifluoroacetic acid salt (lg; 1.53 mmoles, 17A), palladium II acetate(17.2 mg; 0.076 mmoles), tetrakis triphenylphosphine palladium (176.8 mg; 0.153 mmoles), and copper (I) iodide(49 mg; 0,228 mmoles) is added 15 ml of reagent grade acetonitrile in a clean dry 2 necked round bottom flask.
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